Graft survival and clinical outcomes of Descemet membrane endothelial keratoplasty: long-term results
International Ophthalmology, cilt.42, sa.1, ss.269-279, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s10792-021-02078-4
- Dergi Adı: International Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
- Sayfa Sayıları: ss.269-279
- Anahtar Kelimeler: Ocular surface surgery, Corneal dystrophies, Corneal degenerations, Corneal transplantation, Diseases of the ocular surface
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: The aim is to report long-term graft survival rates and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK). Methods: In this study 150 eyes that underwent DMEK whether for Fuchs endothelial corneal dystrophy (FECD) or for bullous keratopathy (BK) surveilled for 7 years at 6 time points to evaluate graft survival rates and clinical outcomes of post-corneal transplantation. Results: Overall, the estimated survival probability of 95% confidence interval at 7 years of post-DMEK was 0.58 (0.72–0.77), and the survival probabilities of eyes operated for FECD (0.53) were higher than eyes operated for BK (0.42) (log rank 26.87, [p = 0.197]). Post-transplant eyes with FECD achieved better visual acuity levels than eyes with BK (p = 0.006). Primary graft failure occurred in 11.3% eyes. Secondary graft failure rate was 9.3%, and allograft rejection rate was 4.7%. Conclusion: Although DMEK is effective and safe in long term, visual results and graft survival rates are better in cases with FECD.