Predictive role of de ritis ratio in biochemical recurrence after radical prostatectomy Radikal prostatektomi sonrası biyokimyasal rekürrens tahmininde de ritis oranının rolü
Haseki Tip Bulteni, cilt.58, sa.1, ss.84-93, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.4274/haseki.galenos.2019.5592
- Dergi Adı: Haseki Tip Bulteni
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.84-93
- Anahtar Kelimeler: De Ritis ratio, prostate cancer, biochemical recurrence, pathological findings, biochemical recurrence-free survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To analyze the role of De Ritis (aspartate aminotransferase/ alanine aminotransferase) ratio in predicting biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: We retrospectively evaluated 425 patients with localised prostate cancer who underwent RP from 2009 to 2018. Patients with neo-adjuvant treatment, elevated liver enzymes, postoperative early hormone therapy, incomplete clinicopathological data and a follow-up of less than 6 months were excluded from the study. Demographic, clinical, pathological and follow-up data of the patients were recorded. Patients with and without BCR were compared. Sensitivity and specificity of De Ritis ratio in predicting BCR were calculated. Results: According to the maximum value of the Youden index, optimal threshold of De Ritis ratio for BCR was 1.1. Sensitivity, specificity, positive predictive value and negative predictive value were 69.7%, 61.1%, 37.6% and 85.7%, respectively. Multivariate analysis showed that the De Ritis ratio (HR=1.968, p=0.014) was a significant predictor factor for BCR. BCR-free survival rate was significantly lower in patients with higher De Ritis ratio. Conclusion: Our study suggests that elevated De Ritis ratio and detailed pathological findings could be an independent predictive factor for BCR after RP.