Survival and treatment outcomes in patients with extracranial oligometastatic breast cancer: Single-center experience
Turk Onkoloji Dergisi, cilt.35, sa.3, ss.327-333, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.5505/tjo.2020.2278
- Dergi Adı: Turk Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.327-333
- Anahtar Kelimeler: Breast cancer, oligometastases, survival
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE Oligometastatic tumors are usually characterized by a solitary or small number of metastatic lesions confined to a single organ. This study aims to investigate the prognostic factors for overall survival in patients with extracranial oligometastatic breast cancer and share our own experiences. METHODS We evaluated 130 patients who were admitted for the diagnosis of extracranial oligometastatic breast cancer at the University of Health Sciences Istanbul Training and Research Hospital Department of Radiation Oncology between 2013 and 2017. RESULTS Age (p=0.003), type of surgery (p<0.001), estrogen receptor status positivity (p=0.011), location of metastasis (p<0.001), premenopausal status (p=0.001), number of metastases (p=0.029), administration of chemotherapy (p<0.001) and application of curative radiotherapy (p<0.001) were the prognostic factors affecting overall survival in univariate analysis. Age<50 (HR: 5.434; 95% CI: 1.025-28.80; p=0.047), only bone metastasis (HR: 0.165; 95% CI: 0.073–0.370; p<0.001), premenopausal status (HR: 0.125; 95% CI: 0.022–0.723; p=0.020) and chemotherapy administration (HR: 4.342; 95% CI: 1.792–10.52; p=0.001) were independent prognostic factors that positively affected overall survival in multivariate analysis. CONCLUSION Oligometastatic breast cancer is a separate subgroup with long-term prognosis for patients with meta-static breast cancer. In patients with extracranial oligometastatic breast cancer, long-term disease control may be possible using more aggressive multidisciplinary treatments, particularly in patients with bone-only metastases.