Follow-up of corrected QT interval in the detection of doxorubicin cardiomyopathy: An experimental study Doksorubisine baǧli kardiyomiyopatinin saptanmasinda düzeltilmiş QT intervali takibi: Deneysel bir çalişma
Turk Kardiyoloji Dernegi Arsivi, cilt.29, sa.6, ss.354, 2001 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 6
- Basım Tarihi: 2001
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.354
- Anahtar Kelimeler: Cardiomyopathy, Doxorubicin, QT interval
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Comprehensive cardiac evaluations are recommended for all doxorubicin-treated patients to detect subclinical cardiac failure. In this study we examined the prolongation of corrected QT interval (QTc) in doxorubicin treated rabbits. Male New Zealand rabbits (n=24) were randomised into two groups. Group A (n=12) was given doxorubicin (2mg/kg once a week) and group B (n=12) was given saline during 10 weeks. QTc intervals were measured in every two weeks from extremity leads for each animal. At the end of the study cardiac samples were examined histologically and each animal was given a histopatological score between 0 and 4 according to degree of cardiomyopathy. Hitopatological score were 3 for one rabbit and 4 for the remaining 11 rabbits in grouup A and were 0 for all the rabbits in group B. QTc intervals at the beginning and at the end of the study were 248.5±17.7 msec. and 298.8±13.7 msec. consecutively (p≅0.012) in group A, 243.8±17.6 msec. and 245.4±17.8 msec. consecutively (p>0.05) in group B. Prolongation of QTc was statistically significant at the end of the 4th week (262.3±17.9 msec.) when compared with the basal value in Group A (p>.05). As a result, prologation of QTc, measure of myocardial repolarization may reflect injury to myocardial cells and is an easy inexpensive method that can be used in the detection of subclinical cardiomyopathy in doxorubicin treated patients.