Evaluation of Endoplasmic Reticulum Stress in Endometriosis Patients by Determination of Serum X-box Binding Protein 1 Levels
Journal of Reproductive Medicine, cilt.66, sa.11-12, ss.365-370, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 66 Sayı: 11-12
- Basım Tarihi: 2021
- Dergi Adı: Journal of Reproductive Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, Veterinary Science Database
- Sayfa Sayıları: ss.365-370
- Anahtar Kelimeler: endometriosis, endoplasmic reticulum stress, pain, unfolded protein response, X-box binding protein 1 (XBP-1)
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To evaluate endoplasmic reticulum stress levels in the presence of endometriosis by comparing the serum X-box binding protein 1 (XBP-1) levels between endometriosis patients and a healthy control group. STUDY DESIGN: A total of 86 patients who were pre-viously diagnosed with en-dometriosis with persistent endometriomas were included in the study group. Six-ty healthy subjects were re-cruited to the control group. Serum XBP-1 levels were determined and pain symptoms were evaluated using visual analogue scale (VAS). RESULTS: The area under curve for XBP-1 levels in the study group was 91% (95% CI 0.860–0.960, p<0.001) for the cutoff value of 1,279.52 with a sensitivity of 87.2%, specificity of 86.7%, PPV 90.4%, NPV 82.5%, +LR 6.5, and −LR 0.1. The area under curve for VAS scores ≥6 was 96.2% (95% CI 0.930–0.980, p<0.001) for the cutoff value 2,227.71, with a sensitivity of 90% and a specificity of 91.1%. In addition, a significant positive correlation between XBP-1 levels and endome-trioma volume and VAS score was observed (r =0.51; r =0.79; r =0.65, respectively; p<0.001). CONCLUSION: XBP-1 levels in the study group were significantly higher than those of the control group. In addition, significantly higher levels of XBP-1 in pa-tients with VAS scores of ≥6 have been reported.