Corneal confocal microscopy and dry eye findings in contact lens discomfort patients
Contact Lens and Anterior Eye, cilt.41, sa.1, ss.101-104, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/j.clae.2017.08.001
- Dergi Adı: Contact Lens and Anterior Eye
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.101-104
- Anahtar Kelimeler: Contact lens, Contact lens discomfort, Dry eye, Corneal confocal microscopy, Dendritiform cells, CLDEQ-8
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives To evaluate the corneal confocal microscopy and dry eye findings in patients with contact lens discomfort. Methods The study included 3 groups of participants: Contact lens wearers using silicone hydrogel soft contact lenses who are symptomatic (CLD, n = 15) or asymptomatic (ACL, n = 11) and non-wearers as controls (n = 14). Duration of contact lens wear, Ocular Surface Disease Index (OSDI) questionnaire responses, fluorescein tear break-uptime (FBUT), and corneal confocal microscopy findings were recorded. Results Mean age was 25.7 ± 8.2 years and male/female ratio was 7/33. Demographic findings were similar regarding the groups. CLD patients had a longer lens use history than ACL (median 5 vs 2 years, p < 0.001). OSDI scores were higher in CLD group than ACL or controls (p < 0.001, p = 0.002). FBUT was significantly lowest in CLD group, compared to controls and ACL (p < 0.001, p = 0.039). FBUT was also lower in ACL patients compared to controls (p = 0.036). There was no difference between basal epithelium cell counts between all 3 groups. Anterior stromal activated keratocyte numbers were similar between contact lens using groups but was lower in controls (p = 0.005). However, dendritiform cells in the sub-basal nerve layer were higher in CLD group compared to controls but similar to ACL (p < 0.001, p = 0.058). Graded sub-basal nerve tortuosity was more prominent in CLD group than the ACL (p = 0.014). Conclusion Patients with CLD had been wearing contact lenses for longer than those without symptoms. OSDI and FBUT scores were worse in CLD patients. In contact lens discomfort patients, there were increased dendritiform cells, indicating intensified inflammatory status of the cornea.