The Relationship between Insulin Resistance and Serum Copeptin Levels in Women with Polycystic Ovary Syndrome Polikistik Over Sendromlu Kadınlarda İnsülin Direnci ile Serum Copeptin Düzeyi Arasındaki İlişki
Sakarya Medical Journal, cilt.12, sa.4, ss.680-686, 2022 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.31832/smj.1113885
- Dergi Adı: Sakarya Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.680-686
- Anahtar Kelimeler: Copeptin, Hyperandrogenism, Insulin resistance, PCOS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective To reveal the possible relationship between insulin resistance and serum copeptin level in women with polycystic ovary syndrome (PCOS). Materials and Methods 44 women with PCOS and 44 healthy women of similar age and body mass index (BMI) were included in the study. Demographic, clinical and laboratory information of the women were obtained from their medical records. Serum copeptin level was measured in the blood sample taken between the 2nd and 4th days of the menstrual cycle. The data of PCOS and healthy women were compared. Correlation of serum copeptin level with variables found to be significant among women was evaluated. Results In women with PCOS, clinically infertility, hirsutism, acne, oily skin and hair loss were more common, Ferriman-Gallwey Score (FGS) was higher, and the interval between menstruel periods was longer (p <0,05 for all variables). In women with PCOS, LH, Free testosterone, total testosterone, DHEASO4, fasting insulin, HOMA-IR and copeptin levels and insulin resistance rate were found to be high (p <0.05 in all variables). Serum copeptin levels were positively correlated with HOMA-IR, fasting insulin, AMH, total testosterone, free testosterone, and LH levels in decreasing order (p1:0,728, p2:0,692, p3:0,440, p4:0,431, p5:0,378, p6:0,359, respectively). Conclusion Serum copeptin level is high in women with PCOS. The serum copeptin level is also correlated with the level of AMH and androgens, especially the markers of insulin resistance.