Effect of the povidone iodine, hypertonic alkaline solution and saline nasal lavage on nasopharyngeal viral load in COVID-19
Clinical Otolaryngology, cilt.48, sa.4, ss.623-629, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.1111/coa.14056
- Dergi Adı: Clinical Otolaryngology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Sayfa Sayıları: ss.623-629
- Anahtar Kelimeler: COVID-19, hypertonic alkaline solution, nasopharyngeal viral load, povidone-iodine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The present study aimed to investigate the in vivo activity of nasal irrigation (NI) with saline, NI with povidone–iodine (PVP–I) 1%, NI with a mix of hypertonic alkaline and PVP–I 1% against Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Design: This study was a prospective randomised clinical trial. Setting: A multicenter study involving tertiary care centres. Participants: The study included adult outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal swabs were positive. One hundred twenty patients were divided into four equal groups. Standard COVID-19 treatment was given to Group 1, NI containing saline was added to patients' treatment in Group 2, NI containing 1% PVP–I solution was added to patients' treatment in Group 3, and NI containing 1% PVP–I solution and the hypertonic alkaline solution was added to patients' treatment in Group 4. Main Outcome Measures: On the first day of diagnosis (Day 0), nasopharyngeal swab samples were taken, on the third and fifth days the nasopharyngeal viral load (NVL) reduction in quantitative RT-PCR test was calculated. Results: Between the zeroth to third days and zeroth to fifth days, the NVL reduction was significant in all groups (p <.05). In paired comparisons of groups, the NVL decrease in Group 4 in the first 3 days was significantly lower than all groups (p <.05). The NVL decrease in Groups 3 and 4 in the first 5 days were significantly lower than Group 1 (p <.05). Conclusion: This study revealed that the use of NI of 1% PVP–I and the hypertonic alkaline solution mixture was more effective in reducing NVL.