Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging Pankreatik Dokunun Yoğun FAPI Tutulumu Pankreas Kanserinin Tümör Aktivitesini Maskeleyebilir: Çift İzleyici PET Görüntülemenin Önemi
Molecular Imaging and Radionuclide Therapy, cilt.35, sa.1, ss.70-72, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/mirt.galenos.2025.91069
- Dergi Adı: Molecular Imaging and Radionuclide Therapy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.70-72
- Anahtar Kelimeler: FAPI, Gallium-68, pancreatic cancer, FDG, PET/CT
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers. Pancreatic cancer is characterized with [68Ga]Ga-FAPI-04 and 18F-fluorodeoxyglucose (18F-FDG) uptake in varying degree. However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging. We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [68Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in 18F-FDG PET/CT images.