Serum IGF-I and IGFBP-3 in healthy pregnancies and patients with preeclampsia
Clinical Biochemistry, cilt.36, sa.3, ss.221-223, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 3
- Basım Tarihi: 2003
- Doi Numarası: 10.1016/s0009-9120(03)00008-0
- Dergi Adı: Clinical Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.221-223
- Anahtar Kelimeler: IGF-I, IGF-I/IGFBP-3, preeclampsia
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Design and methods: We studied serum levels of IGF-I and IGFBP-3 in 68 pregnant women; 28 mild preeclampsia, 13 severe preeclampsia, and 27 healthy pregnant control subjects. Results: When compared with the healthy pregnant group preeclampsia groups had markedly decreased mean serum IGF-I levels. The difference was also significant between the mild and severe preeclampsia groups. Serum mean IGFBP-3 level was also lower in both preeclampsia groups than in healthy pregnancy group, but the difference between the preeclampsia groups did not reach significance. For IGF-I/IGFBP-3 ratio, the mean levels were significantly lower in mild and severe preeclampsia groups than in healthy pregnancy group. Also the mean IGF-I/IGFBP-3 ratio was significantly lower in the severe preeclampsia group compared with the mild preeclampsia group. Conclusion: IGF-1 and IGFBP-3 levels in patients with preeclampsia were compared with healthy pregnant control subjects. IGF-I and IGF-I/IGFBP-3 ratio may be useful for estimate the severity of preeclampsia. © 2003 The Canadian Society of Clinical Chemists. All rights reserved.