The impact of tamoxifen treatment on voice parameters in premenopausal women with breast cancer
European Archives of Oto-Rhino-Laryngology, cilt.281, sa.2, ss.1025-1030, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 281 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.1007/s00405-023-08328-8
- Dergi Adı: European Archives of Oto-Rhino-Laryngology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1025-1030
- Anahtar Kelimeler: Acoustics, Voice analysis, Estrogen, Tamoxifen, Breast cancer, Premenopausal women, Objective sound analysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The study aims to investigate the estrogen-agonistic effects of tamoxifen on voice parameters in premenopausal women diagnosed with breast cancer. Methods: A total of 108 premenopausal women were included, segmented into distinct treatment groups and a control group. Objective sound analysis was conducted using robust statistical methods, employing SPSS 25.0 for data analysis. Results: The study identified a statistically significant reduction in Jitter values across all treatment groups compared to the control group. No significant changes were observed in other voice quality parameters such as F0, Shimmer, NHR, and HNR. Conclusions: The findings suggest that tamoxifen may have an estrogen-agonistic effect on voice quality, thereby potentially influencing future treatment protocols. This research fills a critical void in existing literature and sets the stage for more comprehensive studies that consider affects of hormonal therapies to voice.