Investigation of antifungal susceptibility of trichosporon asahii isolated from urine samples İdrar Örneklerinden İzole edilen trichosporon asahii İzolatlarının antifungal duyarlılığının araştırılması
Medical Journal of Bakirkoy, cilt.17, sa.2, ss.130-134, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/bmj.galenos.2021.54254
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.130-134
- Anahtar Kelimeler: Trichosporon asahii, urinary tract infection, antifungal susceptibility
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: As part of the normal human flora of the skin and gastrointestinal tract, Trichosporon species may lead to opportunistic infections through underlying facilitating factors. Urinary tract infections (UTIs) are the most common infections occurring in intensive care units (ICUs), where catheterization procedures are performed extensively. The aim of the study investigates the antifungal susceptibility of T. asahii strains isolated from urine samples. Methods: Isolates were identified to the species level using the MALDI-TOF MS system (VITEK MS; bio-Mérieux). Antifungal susceptibility tests were conducted using the broth microdilution method, in accordance with the recommendations of the “Clinical and Laboratory Standards Institute (CLSI)”. Results: At a 48-hour assessment of the 100 T.asahii isolates included in the study, the minimal inhibitory concentration (MIC)50 and MIC90 values were (2µg/mL, 8µg/mL) for fluconazole, (0.06µg/mL, 0.12µg/mL) for voriconazole, (0.25 µg/mL, 1 µg/mL) for posaconazole, (0.12 µg/mL, 0.25 µg/mL) for itraconazole and isavuconazole, (2 µg/mL) for amphotericin B and (>8) for micafungin. Conclusion: The lowest and highest MIC values among the triazole antifungal agents were determined for voriconazole and fluconazole, respectively. Considering the high MIC values, care should be taken to prevent breakthrough infections of Trichosporon in at-risk patients undergoing empirical or prophylactic echinocandin or fluconazole therapies.