Human chitinase-3-like protein: A pathogenic role in recurrent implantation failure? İnsan kitinaz-3 protein: Tekrarlayan implantasyon başarısızlığında patojenik rolü var mı?
Medeniyet Medical Journal, cilt.33, sa.2, ss.100-104, 2018 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.5222/mmj.2018.71084
- Dergi Adı: Medeniyet Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.100-104
- Anahtar Kelimeler: Human chitinase-3-like protein 1, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, Recurrent implantation failure
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Human Chitinase-3-like Protein 1 (CHI3L1) (also known as serum human cartilage glycoprotein 39 (YKL-40) is a new biomarker associated with cancer and inflammatory diseases. Hematological parameters also may be called as sensitive markers of inflammation including mean platelet volume (MPV) and systemic inflammatory response (SIR) markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR). In this paper, it was aimed to examine the levels of CHI3L1, MPV, NLR and PLR in patients with recurrent implantation failure (RIF) and compare these values with those of healthy women with proven fertility. The study group consisted of 28 infertile women with RIF characterized by a failure to attain a clinical pregnancy after three consecutive therapeutic cycles of IVF or ICSI. In these processes, first, all embryos must be in good condition and at an appropriate developmental phase-second, the total number of transferred ones should undergo at least four cleavages-stage embryos and minimum two for blastocysts as well. The control group included 28 healthy women with proven fertility that had conceived spontaneously without miscarriages. Hematological parameters were automatically calculated. Irrevelant differences were revealed among the groups with regard to age and body mass indices. Whereas Human Chitinase-3-like Protein 1 levels were similar in RIF (59.6 (38.6-421.2 ng/ml) and control subjects (68.5 (20.6-486.4 ng/ml) (p=0.222). Insignificant differences were found among MPV, NLR and PLR values. Recurrent implantation failure was not associated with altered CHI3L1, MPV, NLR and PLR levels.