Gastrointestinal autonomic nerve tumour of jejunum presenting as a perfore mass
Journal of the Pakistan Medical Association, cilt.64, sa.4, ss.461-464, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 4
- Basım Tarihi: 2014
- Dergi Adı: Journal of the Pakistan Medical Association
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.461-464
- Anahtar Kelimeler: Gastrointestinal autonomic nerve tumour, S-100 protein, Stromal tumour, Small intestine, Jejunum
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Gastrointestinal autonomic nerve tumour (GANT) is a rare mesenchymal neoplasm of the gastrointestinal tract arising from the neural plexus of the intestinal wall. Herein, we present a 70-year-old male patient presenting with a clinical picture of acute abdomen. Examination of the specimen obtained from the small bowel by means of complete resection revealed a relatively soft submucosal mass measuring 4.5×3 cm in size with spindle morphology and high mitotic activity (>10 mitoses per 50 high-power fields). The tumour cells were strong positive for c-kit (CD117), S-100 protein and glial fibrillary acidic protein (GFAP), but did not harbour mutations in the c-kit and PDGFR genes. The diagnosis was based on light microscopy and immunohistochemical verification. We started tyrosine kinase inhibitor 400 mg/day. The patient is currently alive without metastasis at 28 months postoperatively. He is under close follow-up and survival data of the patient will be presented in the later studies.