Outcomes of inhaled nitric oxide in preterm and term infants: A four-year experience in a tertiary neonatal unit Preterm ve term ınfantlarda ınhale nıtrık oksit sonuçlari: Üçüncü düzey yenıdoğan yoğun bakim ünitesindekı dört yillik deneyım
Guncel Pediatri, cilt.18, sa.1, ss.1-14, 2020 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 1
- Basım Tarihi: 2020
- Dergi Adı: Guncel Pediatri
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
- Sayfa Sayıları: ss.1-14
- Anahtar Kelimeler: Inhale nitric oxide, Preterm, Pulmonary hypertension
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
INTRODUCTION: This study aimed at assessing the data of term and preterm neonates with pulmonary hypertension (PH) to characterise patients and the effectiveness of inhaled nitric oxide (iNO). MATERIALS and METHODS: The study cohort treated with iNO between 2015 and 2019 was categorized into two groups according to the gestational age (GA) and timing of PH. RESULTS: Overall 56 neonates were enrolled. Pre-iNO, post-iNO mean airway pressure values, and oxygenation index were significantly higher in the preterm group (p < 0.05). Mean GA and birth weight of the infants who had early PH diagnosis were higher. Positive responders were more likely to have higher GA as well as higher birth weight (p < 0.05). Non-responders were mostly diagnosed with diaphragmatic hernia in term infants and with sepsis in preterm infants CONCLUSIONS: Despite term infants have higher positive response rate to treatment, initiating early treatment will increase the rate of positive response in preterm infants.