Correlations between left ventricle regional systolic and diastolic functions determined by tissue Doppler echocardiography and myocardial perfusion determined by quantitative rest 99mTc MIBI gated SPECT in patients with dilated cardiomyopathy Dilate kardiyomiyopatili hastalarda doku Doppler ekokardiyografiyle belirlenen sol ventrikül bölgesel sistolik ve diyastolik fonksiyonlari ile istirahat kantitatif 99mTc MIBI gated SPECT ile belirlenen miyokard perfüzyonu arasindaki ilişki
Turk Kardiyoloji Dernegi Arsivi, cilt.34, sa.7, ss.419-424, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 7
- Basım Tarihi: 2006
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.419-424
- Anahtar Kelimeler: Cardiomyopathy, dilated, Echocardiography, doppler, Myocardial ischemia, Myocardial reperfusion, Tomography, emission-computed, single-photon, Ventricular function, left
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: We investigated correlations between regional rest myocardial perfusion and regional systolic and diastolic myocardial velocities assessed by 99mTc MIBI gated single-photon emission computed tomography (G-SPECT) and tissue Doppler echocardiography, respectively, in dilated cardiomyopathy (DCM). Study design: The study included 32 patients (27 men, 5 women; mean age 63±12 years) with DCM, with NYHA functional capacity II-IV. Twenty-five patients had ischemic, seven patients had nonischemic DCM. G-SPECT and tissue Doppler imaging studies were performed using short axis views of the basal, mid, and apical levels of the left ventricle, which was divided into 16 segments. For each segment, regional 99mTc MIBI uptake and peak systolic (Sm), and early (Em) and late (Am) diastolic velocities were determined. Results: The mean Sm value (p=0.007) was significantly higher and the mean 99mTc MIBI uptake (p<0.001) was significantly lower in ischemic patients. There was a very good correlation between ejection fractions obtained by the two methods in ischemic (r=0.81, p<0.001) and nonischemic (r=0.76, p=0.05) groups. Regional perfusion levels showed weak but significant correlations with Sm, Em, and Em/Am in the ischemic group. When 99mTc MIBI uptake levels of ischemic patients were assessed in four groups (≥75%, 75% to 50%, 50% to 25%, <25%), Sm values of the first two were significantly higher than that of the group with <25% uptake (p=0.007, p=0.002, respectively). Sm, Em, and Em/Am values were not correlated with 99mTc MIBI uptake in the nonischemic group. Conclusion: Myocardial flow velocities determined by Doppler echocardiography are correlated with perfusion abnormalities detected by G-SPECT in ischemic DCM.