INFLAMMATION INDICES PREDICT STENT THROMBOSIS IN GERIATRIC PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION
Turk Geriatri Dergisi, cilt.29, sa.3, ss.285-295, 2026 (SCI-Expanded, SSCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.29400/tjgeri.2026.500
- Dergi Adı: Turk Geriatri Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.285-295
- Anahtar Kelimeler: Aged, Biomarkers, Inflammation, ST Elevation Myocardial Infarction, Stent, Thrombosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: The objective of this investigation was to determine whether the systemic immune-inflammation index (SII) and pan-immune-inflammation value (PIV), which serve as comprehensive indicators of systemic inflammatory pathways, possess the prognostic capacity to identify future stent thrombosis (ST) in geriatric STEMI patients. Materials and Method: We comprehensively screened a consecutive cohort of 1,683 elderly individuals (aged 75.3 ± 6.8 years; 64.6% male) who had been treated with primary percutaneous coronary intervention (PCI) for acute ST-elevation myocardial infarction (STEMI). Stratification was performed based on the clinical manifestation of angiographically confirmed ST during follow-up. Both SII and PIV scores were computed from standard complete blood counts obtained at the time of initial clinical presentation. Results: Over an average follow-up duration of 30 ± 10 months, definite ST was documented in 104 individuals (6.2%). Patients experiencing ST exhibited distinct baseline profiles, characterized by a higher prevalence of tobacco use and hypertension, a greater frequency of early dual antiplatelet therapy (DAPT) cessation (<30 days), prolonged total stent lengths, and markedly elevated baseline high-sensitivity C-reactive protein (hs-CRP), SII, and PIV levels. In multivariable Cox proportional hazards modeling, both admission PIV and SII emerged as robust, standalone indicators of subsequent ST. Furthermore, correlation analyses demonstrated that hs-CRP levels fluctuated in tandem with both SII (r=0.342, p<0.001) and PIV (r=0.268, p<0.001) values. Conclusion: In summary, these data demonstrate that baseline immuno-inflammatory indices serve as independent and highly reliable indicators of subsequent ST development within the high-risk geriatric cohort treated with primary PCI for STEMI.