Therapeutic lifestyle change intervention in metabolic syndrome decreases plasma visfatin levels
Anatolian Journal of Clinical Investigation, cilt.2, sa.2, ss.58-62, 2008 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 2
- Basım Tarihi: 2008
- Dergi Adı: Anatolian Journal of Clinical Investigation
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.58-62
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: We aimed to investigate the relationship of visfatin with the components of MS, and plasma adiponectin levels. Also we searched for the effect of therapeutic lifestyle change (TLC) on these parameters. Methods: Nineteen patients [5 male, 14 female; mean age 51.0±9.3 years; body mass index (BMI) 31.0±5.1 kg/m2] and age, sex, BMI matched 20 healthy controls (9 male, 11 female; mean age 45.4±9.3 years; BMI 30.1±4.0 kg/m2) were enrolled. Plasma visfatin levels were measured along with the BMI, waist circumference (WC), blood pressure, lipids, glucose, immunoreactive insulin, adiponectin and hsCRP levels both before and six weeks after the TLC. The insulin sensitivity index was quantified using homeostasis model assesment index (HOMA). Results: Plasma insulin and HOMA levels of the patients were significantly higher and adiponectin levels were significantly lower than the controls. The plasma visfatin levels were not significantly different in both groups. After six weeks of TLC; the BMI, WC, triglyceride, insulin, HOMA and visfatin levels of the patients decreased while the adiponectin levels increased significantly. No correlation was established between the plasma visfatin levels and the other parameters. Conclusions: The results show that plasma visfatin levels decrease along with the improvement of the metabolic parameters due to therapeutic lifestyle changes in patients with MS.