Evaluation of Glucose-6-Phosphate Dehydrogenase Deficiency in Patients with Sickle Cell Anemia
Van Medical Journal, cilt.32, sa.1, ss.27-30, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.5505/vmj.2025.75047
- Dergi Adı: Van Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.27-30
- Anahtar Kelimeler: Glucose-6-phosphate dehydrogenase, hemolysis, sickle cell anemia
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: The aim of this study was to evaluate patients with a diagnosis of Sickle Cell Anemia (SCA) for Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficiency. Materials and Methods: In our study, patients diagnosed with SCA who presented to the Pediatric Hematology and Oncology Clinic at the Adana Faculty of Medicine, Health Sciences University, Adana City Training and Research Hospital, between August 1, 2022, and August 1, 2023, were evaluated. G6PD enzyme data from routine tests performed for the patients were recorded from the patient files or the hospital system. Results: A total of 23 patients diagnosed with Sickle Cell Anemia (SCA) were included in the study. 65.2% (n=15) of the patients were female, and 34.8% (n=8) were male. The ages of the cases ranged from 4 to 30 years, with a median age of 12. Among the cases, 20 were within the age range of 0-18 years (87%), while 3 cases (13%) were over 18 years old. The median G6PD value was found to be 26.28 U/g Hb (2.22-36.98). G6PD deficiency was detected in 2 patients (8.7%), while it was not detected in 21 patients (91.3%). When individuals with G6PD enzyme deficiency were compared to those without, a borderline negative correlation was observed in terms of the fr equency of blood transfusions (p: 0.052, r:-0.410). Conclusion: Screening for G6PD deficiency is necessary in patients with Sickle Cell Anemia (SCA) to prevent deterioration of their condition during treatment. The co-inheritance of both diseases can worsen hemolysis in SCA patients. G6PD scanning enzyme is important in SCA patients.