Comparison of laboratory findings in PCR-positive and IgM-positive Crimean-Congo hemorrhagic fever cases PCR-pozitif ve IgM-pozitif Kırım-Kongo kanamalı ateşi olgularında laboratuvar bulgularının karşılaştırılması
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.78, sa.4, ss.401-410, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.5505/turkhijyen.2021.77854
- Dergi Adı: Turk Hijyen ve Deneysel Biyoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.401-410
- Anahtar Kelimeler: CCHF, fatality, KKKA, thrombocytopenia, trombositopeni, ölüm
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Crimean-Congo hemorrhagic fever (CCHF) develops in one-fifth of the individuals infected with the CCHF virus. The clinical course progresses very rapidly and can result in death within 7-10 days. The aim of this study is to determine whether there is a difference between the PCR-positive period and the IgM-positive period in terms of laboratory findings and to investigate the effect of the difference, if any, on the course of the disease. Methods: Results of 5131 serum samples submitted to public health laboratories for the diagnosis of CCHF between January 1, 2015, and December 31, 2017, were included in the study. PCR and IFA IgM test results of these samples and other laboratory findings of the patients were evaluated. Findings were compared between fatal and non-fatal cases. Results: When laboratory results of the PCR-positive period and IgM-positive period were compared, there was a statistically significant difference in terms of creatinine value, presence of thrombocytopenia (<150,000), platelet count below 20,000, and creatine kinase (CK), lactate dehydrogenase (LDH) and international normalized ratio (INR) levels (p<0.05). In the PCR-positive period, all of these findings were observed to increase detrimentally for the patient. In fatal cases; Presence of thrombocytopenia, platelet count of <20,000/pL, >2.5 mg / dL creatinine level, and CK, LDH and INR values were found to be significantly higher (p<0.05). Conclusion: In our study, the PCR-positive period, or the period in which viremia continues, was found to be a critical period in which all findings deteriorated for the patients. Furthermore, the presence of thrombocytopenia with platelet levels below 20,000/ pL was the most common mortality-related finding (p<0.001). CK, LDH, and INR elevations were determined as other findings related to mortality. We believe these results will assist clinicians in predicting the prognosis and clinical management of the disease.