Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis
B-ENT, cilt.18, sa.3, ss.184-189, 2022 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.5152/b-ent.2022.21096
- Dergi Adı: B-ENT
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.184-189
- Anahtar Kelimeler: Laryngeal squamous cell carcinoma, lymph node metastasis, ERI32, Ki67, P53
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to investigate the expression of estrogen receptor beta 2 receptor in laryngeal squamous cell carcinomas and its relationship with lymph node metastasis. Methods: Histopathological specimens of laryngeal squamous cell carcinoma patients who underwent laryngectomy and neck dissection were evaluated retrospectively. The patients were divided into 2 groups according to the presence of lymph node metastasis. Estrogen receptor beta 2, Ki-67, and p53 antibodies were studied by immunohistochemical methods in the tumoral and non-tumoral tissue specimens. The evaluation of immunohistochemical staining pattern was evaluated with Allred scores. The difference between tumoral and non-tumoral tissues of estrogen receptor beta 2 Allred scores and the relationship of lymph node metastasis with Allred scores of estrogen receptor beta 2 were examined and correlated with Ki-67 and p53 expression. Results: This study included 26 patients in lymph node metastasis (+) group and 46 patients in lymph node metastasis (−) with a total number of 72 patients. There was a significantly higher estrogen receptor beta 2 Allred score of tumoral tissue with respect to non-tumoral tissue (P < .001). Nevertheless, there was no significant relationship between lymph node metastasis (+) group and lymph node metastasis (−) group according to tumoral tissue ERβ2 Allred score (P= .092). Conclusion: Estrogen receptor beta 2 expression was demonstrated significantly in the tumoral tissue of the laryngeal squamous cell carcinoma patients