Diffusing lung capacity of carbon monoxide/alveolar volume as an index for evaluating diffusing capacity of the acromegalic lung
Endocrinologist, cilt.19, sa.6, ss.288-290, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 6
- Basım Tarihi: 2009
- Doi Numarası: 10.1097/ten.0b013e3181c08648
- Dergi Adı: Endocrinologist
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.288-290
- Anahtar Kelimeler: diffusing lung capacity of carbon monoxide, acromegaly, alveolar volume
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and Objectives: Acromegaly alters the structure, elasticity, and function of the entire respiratory apparatus. The purpose of the present study was to compare the diffusing capacity in patients with acromegaly and healthy subjects to elucidate the usefulness of diffusing lung capacity of carbon monoxide/alveolar volume (DLCO/VA) in the evaluation of respiratory functions of patients with acromegaly. Patients and Methods: A total of 75 subjects attending Endocrinology and Metabolism Clinics at Sisli Etfal Training and Research Hospital between May 2007 and May 2008 were enrolled in the study. Results: Acromegaly group included 44 patients (19 males, 25 females; mean age: 46.25 ± 2.1 years). Control group included 31 healthy subjects (9 males, 22 females; mean age: 40.92 ± 1.88). There was no statistical difference in gender distribution between patients and control groups (P > 0.05). Body mass indices were also similar between control and patient groups (P > 0.05). DLCO was similar in patients with acromegaly and healthy subjects (P > 0.05). However, the DLCO/VA was reduced significantly in patients with acromegaly when compared with control values (P < 0.01). Conclusions: DLCO is similar in acromegalic and healthy subjects; DLCO/VA, however, may be a useful index for evaluating the respiratory dysfunction in acromegaly. © 2009 by Lippincott Williams & Wilkins.