Evaluation of bone mineral density in children with type 1 diabetes mellitus

Onder A., ÇETİNKAYA S., Tunc O., Aycan Z.

Journal of Pediatric Endocrinology and Metabolism, cilt.26, sa.11-12, ss.1077-1081, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 11-12
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1515/jpem-2012-0369
  • Dergi Adı: Journal of Pediatric Endocrinology and Metabolism
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1077-1081
  • Anahtar Kelimeler: child, diabetes mellitus, osteopenia, osteoporosis, vitamin D
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Factors such as vascular/neurological mechanisms, poor glycemic control, abnormalities in vitamin D/calcium, secondary hyperparathyroidism, and hypercalciuria have been blamed for the unfavorable effects of type 1 diabetes mellitus (type 1 DM) on bone health. In this present study, we aimed to evaluate the frequency of low bone mineral density (BMD) in children with type 1 DM. Method: Among 100 type 1 DM patients, a 25-hydroxy vitamin D level of < 10 ng/mL was accepted as vitamin D deficiency and the level of 10-20 ng/dL was accepted as vitamin D insufficiency. BMD was measured, and Z-scores were evaluated according to adjusted Turkish standards. Participants with a Z-score of δ -2 were defined as having low BMD; BMD between -2 and -1 were defined as being in the low range of normality; and values ε -1 were accepted as normal. Results: The vitamin D deficiency and insufficiency ratios were 28% and 43%, respectively. Low BMD and BMD in the low range of normality were diagnosed in 10% and 25% of patients, respectively. There was no difference in vitamin D, parathormone, and metabolic control levels between three groups: with normal BMD, low BMD, and BMD in the low range of normality. BMD Z-scores were not different between the pubertal and prepubertal groups. Conclusion: Detailed evaluation should be performed for BMD in the follow-up of DM to prevent complications by decreasing related risks.