Involvement of serotonergic system in cannabinoid analgesia
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, Springer New York, ss.277-295, 2013
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/978-1-4614-7940-6_13
- Yayınevi: Springer New York
- Sayfa Sayıları: ss.277-295
- Anahtar Kelimeler: 5-HT, Cannabinoid analgesia, CB1 agonists, CB2 agonists, Serotonergic neuromodulation, Serotonergic system
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Plant cannabinoids have been used historically as a therapeutic agent in some folk medicine for the treatment of headache, fibromyalgia, and irritable bowel and related conditions in which serotonergic pathways are considered to play a crucial role in pathogenesis and treatment modalities. Serotonergic system has important modulatory role in acute and chronic pain conditions. The analgesic efficacy of cannabinoids in acute and chronic pain appear to be mediated, at least in part, through the regulation of the serotonergic system. In this chapter, we review the interaction between cannabinoids and serotonergic system in the peripheral, spinal and supraspinal sites with special emphasis on serotonin in central sites by which cannabinoid CB1 receptor activation reinforce descending serotonergic pathways to produce antinociceptive effects.