The effect of vitamin D and bisphosphonate on fracture healing: An experimental study
Journal of Clinical Orthopaedics and Trauma, cilt.7, sa.2, ss.90-94, 2016 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 2
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.jcot.2016.01.003
- Dergi Adı: Journal of Clinical Orthopaedics and Trauma
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.90-94
- Anahtar Kelimeler: Bisphosphonates, Experimental study, Fracture healing, Osteoporosis, Vitamin D supplements
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The aim of the study was to evaluate the effects of the using bisphosphonate, vitamin D, and a combination of bisphosphonate and vitamin D on fracture healing, by comparison of radiological and histological findings of the study groups and a control group. Methods: A total of 24 rats were randomly divided into 4 groups. A mid-third fracture was created in the femur of all rats. Saline was administered to Group A, bisphosphonate (Alendronate) to Group B, bisphosphonate (Alendronate) + vitamin D (Calcitriol) to Group C and vitamin D (Calcitriol) to Group D. All preparations were administered orally for 28 days. Results: No statistically significant difference was determined between the groups in respect of the effect on fracture healing according to radiological findings. The histological findings of fracture healing showed Groups B and C to be significantly more advanced than Group A (p = 0.017, p = 0.009). However no significant difference was found in Group D comparison with Group A (p = 0.224). Conclusion: According to the histological findings, advanced fracture healing was seen in the groups administered with bisphosphonate or combined bisphosphonate and vitamin D compared to the use of vitamin D alone and the control group. It was concluded that bisphosphonate treatment combined with vitamin D can be used safely without any negative effect on fracture healing.