The relationship between homocysteine and autoimmune subclinical hypothyroidism
International Journal of Medical Biochemistry, cilt.3, sa.1, ss.1-7, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 3 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.14744/ijmb.2019.13008
- Dergi Adı: International Journal of Medical Biochemistry
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1-7
- Anahtar Kelimeler: Atherosclerosis, autoimmunity, Hashimoto’s disease, homocysteine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and au-toimmunity. The aim of this study was to investigate the association between the homocysteine level, lipid parameters, high-sensitivity C-reactive protein (hs-CRP), and autoantibodies in subclinical hypothyroid patients. Methods: A total of 100 cases, 50 patients who were older than 18 years of age and diagnosed with subclinical hy-pothyroidism due to Hashimoto’s thyroiditis and 50 controls with no known disease, were included in the study. Results: Homocysteine (9.6 µmol/L vs 5.5 µmol/L; p<0.001), hs-CRP (2.4 mg/L vs 0.9 mg/L; p<0.001), and low-density lipoprotein-cholesterol levels (115.9±32.7 mg/dL vs 100.3±23.9 mg/dL) (p=0.008) were determined to be higher in the subclinical hypothyroidism group, and the high-density lipoprotein (HDL) cholesterol level (51.2±12.7 mg/dL vs 58.8±15.2 mg/dL; p=0.008) was lower in the subclinical hypothyroidism group compared with the healthy control group. A positive correlation was determined between the homocysteine level and the hs-CRP (r=0.312; p=0.027), anti-thyroid peroxidase (r=0.505; p<0.001), and anti-thyroglobulin (r=0.318; p=0.031) levels in the subclinical hypothyroidism group. Conclusion: In the regression analysis performed, HDL cholesterol, hs-CRP, and homocysteine levels were each found to be an independent risk factor for subclinical hypothyroidism. Our results indicated that homocysteine was associated with subclinical hypothyroidism.