The effect of tumor budding index on clinical parameters in early-stage oral cavity cancers
Acta Oto-Laryngologica, cilt.146, sa.8, ss.1013-1018, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 146 Sayı: 8
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/00016489.2026.2658632
- Dergi Adı: Acta Oto-Laryngologica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Psychology & Behavioral Sciences Collection (EBSCO)
- Sayfa Sayıları: ss.1013-1018
- Anahtar Kelimeler: Oral cavity cancer, squamous cell carcinoma, tumor budding
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Tumor budding is an established prognostic marker in colorectal cancer however, it is not routinely incorporated into risk assessment in oral cavity squamous cell carcinoma. Aims: To evaluate the impact of tumor budding on survival outcomes and lymph node metastasis in patients with oral cavity cancer undergoing surgical treatment. Material and Methods: Between January 1, 2010 and January 1, 2021, 87 patients diagnosed with oral cavity cancer and who underwent surgery at our clinic were included in the study. Clinically T1-2 was observed in 60 patients (69%), T3-4 in 27 patients (31%), and neck dissection was not performed in 8 patients with T1N0M0 due to comorbidities. Results: The most common site was the tongue in 61 cases (70.1%), followed by the buccal mucosa in 15 cases (17.2%). The median follow-up period was 46.5 months (0.3–160.9). Tumor budding was identified as an independent predictor of overall survival, disease-free survival, and lymph node metastasis in early-stage oral cavity squamous cell carcinoma. Conclusion: The presence of budding was associated with an increased risk of lymph node metastasis and shorter overall and disease-free survival. Significance: Routine assessment of tumor budding may contribute to postoperative risk classification and follow-up planning, beyond staging parameters.