Colorectal carcinomas: Clinicopathologic investigation, correlation with expression of estrogen and progesterone receptors
Turkish Journal of Cancer, cilt.38, sa.3, ss.118-122, 2008 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 3
- Basım Tarihi: 2008
- Dergi Adı: Turkish Journal of Cancer
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.118-122
- Anahtar Kelimeler: Colorectal adenocarcinoma, Estrogen receptor, Progesterone receptor
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Correlation in mortality data between breast cancer and colonic cancer, and increased incidence of colonic cancer in women with breast cancer suggest common factors in their etiology. Similarly protective effect of increasing parity from colonic cancer, and relatively better prognosis in women may imply a common role for sex steroid hormones. In this study clinicopathologic parameters as well as estrogen and progesterone receptor expressions of 60 cases of colorec-tal adenocarcinoma were investigated. Most carcinomas were moderately differentiated; stage B2 tumors were predominately located in the rectosigmoid area. Immu-nohistochemically, no nuclear staining was demonstrated for estrogen or progesterone receptors; only six displayed cytoplasmic staining with estrogen receptor. Although potential importance of estrogen and progesterone receptors has been emphasized by certain reports, its importance is still controversial in terms of both prognosis and management. Moreover, it is unclear whether to exclude cy-toplasmic staining. The significance of these receptors in colorectal carcinoma needs to be further studied.