Relationship between tumor parameters in Ga-68 PSMA PET/ CT and pathological grade grouping in patients with prostate cancer
International Journal of Radiation Research, cilt.23, sa.2, ss.277-281, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.61186/ijrr.23.2.3
- Dergi Adı: International Journal of Radiation Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.277-281
- Anahtar Kelimeler: Ga-6 8 PSMA PET/CT, prostate cancer, pathological grade grouping
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The study aims to explore the relationship between tumor parameters acquired from Ga-68 PSMA PET/CT and GG system in patients who had prostate cancer. Materials and Methods: One hundred and fourteen patients diagnosed with prostate cancer and who underwent Ga-68 PSMA PET/CT imaging for staging purposes were enrolled. The imaging was performed using a Siemens Biograph Horizon-3R 16 slice PET/CT device, and the tumor parameters (SUVmax, SUVmean, and Tumor volume) were calculated by an experienced nuclear medicine physician. Results: There was a correlation between GG with SUVmax (p:0.010; r:0.241) and SUVmean (p:0.06; r:0.258). In redicting high-risk patients, ROC analysis was conducted for SUVmax and SUVmean, resulting in significant cut-off values for both parameters. A cut-off value of 9.8 for SUVmax resulted in a sensitivity of 69% and a specificity of 58%. 5.8 cut-off value for SUVmean resulted in 68% sensitivity and 58% specificity. Tumor volume was found to be a significant predictor for distant metastasis. When a cut-off value of 11.53 cm3 was used for tumor volume, sensitivity was found to be 62% and specificity 56%. Conclusion: According to the results, correlation between GG with SUVmax and SUVmax was significant. Additionally, SUVmax and SUVmean were significant predictors of high-risk prostate cancer, while TV was a significant predictor of distant metastases. In summary, Ga-68-PSMA PET CT are deemed a beneficial imaging modality for both prognosis assessment and staging in clinical.