Significance of interleukin-17A and interleukin-23 in chronic rhinosinusitis with nasal polyps

Koca R., EYİGÖR M., Osma U., EYİGÖR H., Yilmaz M. D., SELÇUK Ö. T., ...Daha Fazla

Acta Medica Mediterranea, cilt.33, sa.2, ss.211-216, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.19193/0393-6384_2017_2_031
  • Dergi Adı: Acta Medica Mediterranea
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.211-216
  • Anahtar Kelimeler: Chronic rhinosinusitis, ELISA, IL-17A, IL-23, Nasal lavage, Nasal polyposis, Serum
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Introduction: Several previous studies have investigated the significance of interleukin 17 (IL-17) in the pathogenesis of chronic rhinosinusitis with nasal polyposis; however, the importance of IL-23 has not been studied. We investigated the significance of IL-17 and IL-23 in the pathogenesis of by chronic rhinosinusitis with nasal polyposis measuring the levels of these proinflammatory cytokines in serum and nasal lavage samples. Materials and methods: Twenty-five patients aged > 18 years with chronic rhinosinusitis with nasal polyposis and a control group with 25 healthy subjects were included the study. The levels of IL-17 and IL-23 were measured in the serum and nasal lavage fluids using enzyme-linked immunosorbent assays. Results: The average serum level of IL-17 was 10.2 pg/ml in the study group, and it was 5.0 pg/ml in the control group. The average nasal lavage level of IL-17 was 16.8 pg/ml in the study group compared with 1.0 pg/ml in the control group. There were no statistically significant differences between the groups in the serum levels of IL-17 or IL-23; however, a significant difference between the two groups was found in the lavage fluid levels of IL-17 (p < 0.001). Conclusion: We found a significant difference in the nasal lavage fluid levels of IL-17, which demonstrates the importance of local inflammation. This supports the hypothesis that IL-17 is significant in the pathogenesis of nasal polyposis.