Effect of beta-blocker therapy on left atrial function in patients with heart failure: Comparison of metoprolol succinate with carvedilol
International Journal of Cardiovascular Imaging, cilt.23, sa.5, ss.549-555, 2007 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 5
- Basım Tarihi: 2007
- Doi Numarası: 10.1007/s10554-006-9195-3
- Dergi Adı: International Journal of Cardiovascular Imaging
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.549-555
- Anahtar Kelimeler: heart failure, left atrial function, metoprolol, carvedilol
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We aimed to compare the effects of carvedilol and metoprolol succinate on left atrial (LA) function in patients with chronic heart failure. Methods: Thirty three patients (6 females, 27 males) who had not received β blocker treatment previously and whose left ventricular ejection fraction was below 40% were included in this study. LA volumes were measured echocardiographically just before the time of mitral valve opening (V max), onset of atrial systole (p-wave at the electrocardiography = V p) and mitral valve closure (V min) according to the biplane area length method at baseline and in the 3rd month after the administration of β blockers. NT-proBNP level was measured at the beginning and in the third month of β blocker treatment. The first group was given carvedilol 6.25 mg/day, the second group was given 12.5 mg/day metoprolol succinate and it was increased to the tolerable maximal dose. Results: LA diameter and LA V max, V p, V min decreased significantly both in carvedilol group and metoprolol group after β blocker theraphy (P < 0.01, P < 0.01, P < 0.05, P < 0.05 for metoprolol, P < 0.001, P < 0.01, P < 0.01, P < 0.01 for carvedilol). But it was increased in conduit volume (P < 0.05 for two groups). LA-passive emptying fraction, LA-active emptying fraction and reservoir fraction were no significant differences both in carvedilol group and metoprolol group after β blocker theraphy. NT-proBNP levels were found to decrease significantly in both groups after β blocker treatment (P < 0.001). Conclusion: Our findings indicate that β blocker treatment leads to a decrease in LA diameters and volumes, and metoprolol succinate and carvedilol had similar effects on this decrease. © 2006 Springer Science+Business Media, Inc.