Evaluation of the relationship between lymphoma predictors, disease activity, and netrin-1 in primary Sjögren’s syndrome Primer Sjögren sendromunda hastalık aktivitesi, lenfoma prediktörleri ve netrin-1 arasındaki ilişkinin değerlendirilmesi
Journal of Turkish Society For Rheumatology, cilt.15, sa.3, ss.129-136, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/raed.galenos.2023.24633
- Dergi Adı: Journal of Turkish Society For Rheumatology
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.129-136
- Anahtar Kelimeler: lymphoma, netrin-1, Primary Sjögren’s syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: One-third of patients with primary Sjögren’s syndrome (PSS) do not have anti-SSA or-SSB antibodies. The risk of developing B-cell non-Hodgkin lymphoma (NHL) in PSS is significantly increased, and its prevalence is approximately 5%. There is a continuing need for new markers that can have diagnostic value in PSS and predict lymphoma development. In this study, we aimed to investigate the usability of netrin-1 as a diagnostic marker in PSS and its relationship with disease activity and predictors of lymphoma. Methods: Fifty-two PSS patients and 62 healthy volunteers were included in the study. The European Alliance of Associations for Rheumatology Sjögren’s syndrome disease activity index (ESSDAI) was used to evaluate systemic disease activity in PSS patients. Netrin-1 values were calculated by the quantitative sandwich enzyme immunoassay method using an ELISA kit (catalog number: E-EL-H2328; Elabscience, lot number: GZWTKZ5SWK, Texas, USA). Results: Serum netrin-1 levels were similar in PSS [90.3 (43.87-166.41)] and healthy controls [111.6 (63.39-171.36)] (p=0.190). Netrin-1 serum levels were associated only with lymphopenia (p=0.014), one of the predictive markers of lymphoma in PSS, but not with other markers (p>0.05) and ESSDAI score (r=0.637, p=0.067). Conclusion: Serum netrin-1 levels are not high in PSS and there is no significant correlation between netrin-1 and lymphoma predictive values, except lymphopenia, and the ESSDAI score, which is an indicator of disease activity.