Undetected Peripheral Arterial Disease Among Older Adults With Alzheimer’s Disease and Other Dementias
American Journal of Alzheimer's Disease and other Dementias, cilt.33, sa.1, ss.5-11, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1177/1533317517724000
- Dergi Adı: American Journal of Alzheimer's Disease and other Dementias
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.5-11
- Anahtar Kelimeler: peripheral arterial disease, dementia, Alzheimer's disease, vascular dementia, ankle-brachial index, elderly
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Peripheral arterial disease (PAD) was reported to increase the risk of dementia(s) even more than stroke. We assessed the prevalence of PAD in a group with definite diagnosis of dementia. Methods: Patients aged 65 years or older with Alzheimer’s disease (AD), vascular dementia (VaD), or AD-VaD were enrolled (n = 162, mean age: 78.87 [6.05] years). An age- and gender-matched control group was also included (n = 190). Peripheral arterial disease was diagnosed by the ankle–brachial index. Results: Frequency of PAD among patients with and without dementia was 35.2% and 16.3%, respectively (P <.001), being similar among different types of dementia. After adjustment for covariates, dementia (odds ratio: 2.41, 95% confidence interval: 1.34-4.32; P =.003) was among the predictors of PAD diagnosis along with older age, female gender, and diabetes. Conclusions: The prevalence of PAD was more than double in patients with dementia, with no difference among AD, VaD, and AD-VaD types.