Monocyte to High-Density Lipoprotein Cholesterol Ratio Could be a Predictor of Dialysis Adequacy?
SN Comprehensive Clinical Medicine, cilt.8, sa.1, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s42399-026-02271-5
- Dergi Adı: SN Comprehensive Clinical Medicine
- Derginin Tarandığı İndeksler: Scopus, EMBASE, Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: Chronic kidney disease, Dialysis adequacy, Hemodialysis, Inflammation, Monocyte to high-density cholesterol ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is a marker of inflammation and cardiovascular risk in chronic kidney disease (CKD), but its role in hemodialysis (HD) adequacy remains unexplored. Aim: To investigate the association between MHR and dialysis adequacy in HD patients. Methods: In a cross-sectional study of 145 HD patients across three centers in Türkiye, pre-dialysis MHR was calculated, and dialysis adequacy was assessed using Kt/V (≤ 1.3 indicating inadequacy). Pearson’s correlation and Mann-Whitney U tests were used for analysis. Results: Of 145 patients (51% female, mean age 53.2 ± 14.7 years), 30 (20.7%) have inadequate dialysis (Kt/V ≤ 1.3). MHR was higher in the inadequate dialysis group (17.1 ± 8.6 vs. 13.3 ± 5.6, p = 0.028) and inversely correlated with Kt/V (r=-0.23, p = 0.028). Female predominance was observed in the inadequate dialysis group (83.3% vs. 42.6%). Conclusion: Higher MHR is associated with lower dialysis adequacy, suggesting its potential as a cost-effective biomarker for HD monitoring. Longitudinal studies are needed to validate these findings.