Preoperative serum IL-6 levels: Clinical importance in gastric carcinoma with lymph node metastasis Mepreoperatif serum IL-6 düzeyleri; lenfnodu metastazlı mide kanserinde klinik önemi
European Journal of General Medicine, cilt.7, sa.4, ss.410-413, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 4
- Basım Tarihi: 2010
- Doi Numarası: 10.29333/ejgm/82894
- Dergi Adı: European Journal of General Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.410-413
- Anahtar Kelimeler: Gastric carcinoma, IL-6, Lymph node, Metastasis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis. The purpose of this study was to investigate the preoperative serum levels of IL-6 in gastric carcinoma with lymph node metastasis, and to correlate them with disease status. Method: A total of 100 patients who underwent gastrectomy were enrolled in this study. Serum levels of IL-6 were assessed enzyme linked immunosorbent assay (ELISA). Histological findings included tumor size, depth of tumor invasion, lymph node (LN) metastasis, and TNM stage. Result:Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 levels were correlated with invasion depth (p<0.001), LN metastasis (p<0.001), and TNM stage. The presence of peritoneal seeding metastasis is associated with IL-6 levels (p<0.001). Conclusion: Preoperative serum IL-6 levels might be markers of tumor invasion, LN metastasis, and TNM stage. These results suggest that IL-6 levels are potential molecular markers that predict lymphatic involvement in gastric carcinoma.