Penetration of topical 0.3% ciprofloxacin into human aqueous humor
Ophthalmic Surgery and Lasers, cilt.27, sa.1, ss.21-24, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 1
- Basım Tarihi: 1996
- Dergi Adı: Ophthalmic Surgery and Lasers
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.21-24
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.