Stimulus properties of venlafaxine in a conditioned taste aversion procedure

Kayir H., Alici T., GÖKTALAY G., Yildirim M., ULUSOY K. G., Ceyhan M., ...Daha Fazla

European Journal of Pharmacology, cilt.596, sa.1-3, ss.102-106, 2008 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 596 Sayı: 1-3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.ejphar.2008.08.015
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.102-106
  • Anahtar Kelimeler: Conditioned taste aversion, Antidepressant, Venlafaxine, Tianeptine, Fluoxetine, Escitalopram, Reboxetine, L-NAME, (Mice)
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Conditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:30-16:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and Nω-nitro-l-arginine methyl ester (l-NAME)] were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution (5% w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. l-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine. © 2008 Elsevier B.V. All rights reserved.