A novel screening biomarker in gastric cancer: Serum Dickkopf-1
Hepato-Gastroenterology, cilt.59, sa.117, ss.1661-1664, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 117
- Basım Tarihi: 2012
- Doi Numarası: 10.5754/hge11516
- Dergi Adı: Hepato-Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1661-1664
- Anahtar Kelimeler: Dickkopf-1 protein, Gastric cancer, Adenocarcinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background/Aims: Despite all the knowledge about gastric cancer, there is no prognostic biomarker which could be useful for early detection. Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway. DKK-1 is reported to be over expressed in many malignant tissues. The purpose of this study was to elucidate the normal level of serum DKK-1 (sDKK-1) levels in healthy Turkish peoples and to investigate the clinical utility of sDKK-1 levels for gastric cancer screening. Methodology: Serum DKK-1 levels were measured in 69 healthy con-trois and in 60 gastric adenocarcinoma patients with ELISA and sDKK-1 levels were compared with clinicopathological features and outcomes in gastric cancer patients. Results: Serum concentrations of DKK-1 in gastric adeno cancer patients were significantly higher than control patients (p<0.001). The optimal cut-off for sDKK-1 levels order to discriminate control group from gastric cancer patients was 25U/mL with sensitivity equal to 100% and specificity equal to 100%. Conclusions: Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers. © H.G.E. Update Medical Publishing S.A.