Serotonin syndrome due to duloxetine
Clinical Neuropharmacology, cilt.34, sa.3, ss.127-128, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1097/wnf.0b013e31821b3aa0
- Dergi Adı: Clinical Neuropharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.127-128
- Anahtar Kelimeler: duloxetine, serotonergic syndrome, serotoninergic agents, selective serotonin reuptake inhibitor
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Serotonin syndrome is a toxic condition due to serotoninergic hyperstimulation, which is caused mostly by serotonergic agents either in overdose or in combination. The diagnosis is purely clinical and poorly validated. We described a patient with tremor, mydriatic pupils, clonus, and ataxia after a single dose of duloxetine; on the dosage of admission. Duloxetine belongs to a large class of antidepressants called reuptake inhibitors. The case is presented to emphasize this possible toxicity due to increasing availability of serotonergic agents. It is a complex but easily preventable and recognizable condition. We believe this to be one of the rare reports of serotonin syndrome associated with duloxetine. Copyright © 2011 by Lippincott Williams & Wilkins.