Morphological pattern of non-diabetic nephropathy in type 2 diabetes mellitus patients Морфологічний патерн недіабетичної нефропатії у хворих на цукровий діабет 2 типу
Ukrainian Journal of Nephrology and Dialysis, sa.2, ss.38-44, 2022 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2022
- Doi Numarası: 10.31450/ukrjnd.2(74).2022.06
- Dergi Adı: Ukrainian Journal of Nephrology and Dialysis
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.38-44
- Anahtar Kelimeler: diabetic nephropathy, glomerulonephritis, kidney biopsy, non-diabetic nephropathy, proteinuria
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of this study was to evaluate the contribution of kidney biopsy performed with an appropriate indication to diagnosis and treatment in diabetic patients with nephropathy. Methods: In this retrospective study 32 type 2 diabetes patients who underwent kidney biopsy in a single center between 2012-2019 were included. Kidney biopsy indications were determined as patients with diabetes without diabetic retinopathy and with proteinuria above 1 g/day. Results: Diabetic (DN) and non-diabetic (NDN) nephropathies were diagnosed with renal biopsy. In 14 (43.7%) of 32 patients, NDN was reported in histopathological evaluation. Membranous nephropathy was detected in 4 of these patients, focal segmental glomerulosclerosis (FSGS) in the other 4 patients, light chain disease in 2 patients, IgA nephropathy in 2 of the patients, minimal change nephropathy in another patient, and finally AA amyloid in one patient. NDRD seen superimposed on DN (DN + interstitial nephritis and DN + FSGS) was observed in 2 patients. DN was detected in 16 (50%) of 32 type 2 diabetic patients. Conclusion: Kidney biopsy in patients with type 2 diabetes is an important tool for diagnosing NDN, choosing the right treatment tactics and determining kidney prognosis.