Intratubal methotrexate for prevention of persistent ectopic pregnancy after salpingotomy
Journal of the American Association of Gynecologic Laparoscopists, cilt.9, sa.4, ss.464-467, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 4
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s1074-3804(05)60520-8
- Dergi Adı: Journal of the American Association of Gynecologic Laparoscopists
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.464-467
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Study Objective. To investigate whether frequency of persistent ectopic pregnancy after linear salpingotomy can be reduced by prophylactic administration of a single intraoperative injection of local methotrexate. Design. Prospective, randomized, controlled trial (Canadian Task Force classification I). Setting. University-affiliated hospital. Patients. Sixty-five women with unruptured ectopic pregnancy. Intervention. Laparoscopic salpingotomy with or without a single intratubal dose of methotrexate 1 mg/kg Measurements and Main Results. In the prophylaxis group, 22 patients received a single dose of intratubal methotrexate 1 mg/kg after linear salpingotomy; 43 controls had only linear salpingotomy. Six women (14%) in the control group developed persistent ectopic pregnancy, compared with none in the prophylaxis group (p <0.05). Conclusion. In our opinion, intratubal methotrexate injection during laparoscopic salpingotomy is a practical option for women with unruptured ectopic pregnancy.