Genetic polymorphism of angiotensin I-converting enzyme (ACE), but not angiotensin II type i receptor (ATr1), has a gender-specific role in panic disorder
Psychiatry and Clinical Neurosciences, cilt.66, sa.2, ss.130-137, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 66 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1111/j.1440-1819.2011.02318.x
- Dergi Adı: Psychiatry and Clinical Neurosciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.130-137
- Anahtar Kelimeler: ACE, ATr1, gender, genetic polymorphism, panic disorder
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims: Angiotensins were shown to have some role in the development of panic disorder (PD). In this study, we aimed to determine the frequency of polymorphisms in two angiotensin-related genes, angiotensin I-converting enzyme (ACE) and angiotensin II type I receptor (ATr1), in a sample of Turkish patients with PD and to evaluate their association with PD development. Methods: Polymerase chain reaction and restriction fragment length polymorphism was used to analyze ATr1 A1166C polymorphism, and only polymerase chain reaction was used to analyze functional ACE insertion/deletion polymorphism in 123 patients with PD and in 169 similarly aged disease-free controls. Results: There was no significant difference in the genotype distribution between PD patients and controls for each polymorphism (P > 0.05). Allele frequency of ACE insertion/deletion was borderline statistically significant between the groups (P = 0.055; odds ratio: 1.39; 95% confidence interval: 0.99-1.95), and allele frequency of ATr1 A1166C was not significantly different between the groups (P = 0.32; odds ratio: 0.81; 95% confidence interval: 0.53-1.22). Conclusion: This study suggests that polymorphisms of ACE I/D and ATr1 A1166C are not associated with risk of PD in Turkish patients. However, in ACE insertion/deletion polymorphism, the insertion allele was found to be more frequent in the male subgroup of patients (π 2 = 4.61, P = 0.032) than in controls, suggesting a potential male-specific role of the less active ACE insertion allele in the pathogenesis of PD. © 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology.