Early predictors of preterm labor and preeclampsia: A prospective study
Gulhane Medical Journal, cilt.59, sa.2, ss.33-38, 2018 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.5455/gulhane.208531
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.33-38
- Anahtar Kelimeler: Beta human chorionic gonadotropin (β-HCG), Doppler ultrasonography, Fms-like tyrosine kinase 1, Matrix metalloproteinase (MMP), Preeclampsia, Pregnancy-associated plasma protein A (PAPP-A), Preterm labor
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aims: This study aimed to investigate various clinical/biochemical parameters as potential predictors of preeclampsia and preterm labor. MMP-2, MMP-9, pregnancy-associated plasma protein A (PAPP-A), fms-like tyrosine kinase 1, and beta human chorionic gonadotropin (β-HCG) levels were measured and Doppler ultrasonography measurements were made in pregnant women at 11-14 weeks of gestation. Findings were recorded and patients were followed until delivery. Results: Patients consisted of preeclampsia and/or preterm labor cases (n=40) and selected controls were pregnant women with a normal pregnancy period who delivered between 37 and 40 weeks of gestation (n=55). Multivariate analysis identified high fms-like tyrosine kinase 1 level (OR, 1.004; 95% CI: 1.001-1.007, p= 0.005), high UtA PI (OR, 30.6; 95% CI: 1.1-852, p= 0.044) and presence of any notch (OR, 36.4; 95% CI: 1.6-826, p= 0.024) as independent predictors of preeclampsia; whereas only maternal MMP-9 level emerged as a significant predictor of preterm birth, (OR, 1.001; 95% CI: 1.000-1.001, p < 0.001). Conclusions: These parameters deserve further investigation for their potential use (either alone or in combination) in the prediction of preeclampsia and preterm birth in the clinical setting.