Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes
Bio-inspired Materials for Biomedical Engineering, Wiley Blackwell, ss.59-76, 2014
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2014
- Doi Numarası: 10.1002/9781118843499.ch4
- Yayınevi: Wiley Blackwell
- Sayfa Sayıları: ss.59-76
- Anahtar Kelimeler: Biomaterial, Biomimetic tissue substitutes, Cell adhesion, Electromagnetic forces, Hydrodynamic forces, Magnetic forces, Substrates, Thermal forces
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Cells have to adhere onto biomaterial surfaces in order for the biomaterial to serve its function. Otherwise, the tissue and the implant stay as separate phases with insufficient interaction, which might eventually lead to extrusion of the biomedical devices. Binding between cells is achieved mainly through gap junctions, tight junctions, adherens junctions, and desmosomes. The main molecules involved in triggering cell adhesion to substrates belong to the integrin family. Mechanobiology investigates the mechanisms of signal transduction from the cell membrane to the cytoskeleton as well as mechanotransduction to the nucleus by way of sequential stimulation of adhesion complexes and secondary messenger proteins on actin filaments. In the tissues, cells are rarely exposed to a single type of mechanical stimulus, and therefore, a bioreactor must ideally simulate simultaneous exposure to a variety of biomechanical forces including hydrostatic, compressive, stretching, and shear.