Association of sets of alleles of genes encoding β3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity
International Journal of Obesity, cilt.24, sa.1, ss.93-100, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 2000
- Doi Numarası: 10.1038/sj.ijo.0801091
- Dergi Adı: International Journal of Obesity
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.93-100
- Anahtar Kelimeler: beta(3) adrenoreceptor, uncoupling protein, lipoprotein lipase, DNA polymorphisms, metabolic disorders of obesity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To investigate the relationship between the polymorphisms of the β3-AR (Trp64Arg), UCP1 (A→G) and LPL (HindIII and PvuII) loci and the metabolic complications associated with obesity in a Turkish population. SUBJECTS: 271 unrelated individuals of Turkish origin including obese (body mass index, BMI > 30 kg/m2) and lean (BMI 125 kg/m2) subjects. MEASUREMENTS: Anthropometric (weight, height and blood pressure) and metabolic measurements (plasma levels of glucose, cholesterol and triglycerides), and determination of β3-AR, UCP1 and LPL genotypes by polymerase chain reaction followed by enzymatic digestion. RESULTS: The distributions of genotypes for each candidate gene (β3-AR, UCP1 and LPL) were similar between the obese and the lean subjects. The Arg64 allele of the β3-AR gene was absent from massively obese men. GG carriers of the A→G variant of the UCP1 gene showed BMI-associated increases of cholesterol levels which were more marked than both AA (P = 0.027) and AG (P = 0.039) carriers. Obese P+ carriers of the LPL PvuII variant had significantly higher levels of glucose than non-carriers (P = 0.011), whereas obese P+P+ carriers did not have significantly different levels of triglycerides than non-carriers (P = 0.087). Moreover, carriers of both alleles (GandP+) had higher levels of glucose than non-carriers (P = 0.048), but did not have significantly different levels of triglycerides than non-carriers (P = 0.125). However, the BMI-associated increase of triglycerides of P+andG carriers was significantly more marked than that of P+ carriers (P = 0.0085). CONCLUSION: Our data support the idea that alleles of specific genes (UCP1, LPL and β3-AR) might play a role in the development of certain metabolic complications of obesity and might have additive effects when combined with each other las in the case of UCP1 and LPL).