Side effects associated with the treatment of multidrug-resistant tuberculosis
International Journal of Tuberculosis and Lung Disease, cilt.9, sa.12, ss.1373-1377, 2005 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 9 Sayı: 12
- Basım Tarihi: 2005
- Dergi Adı: International Journal of Tuberculosis and Lung Disease
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1373-1377
- Anahtar Kelimeler: Multidrug resisistance, Side effects, Tuberculosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
SETTING: Süreyyapaşa Centre for Chest Diseases and Thoracic Surgery, Istanbul, Turkey. OBJECTIVE: To report the frequency of treatment side effects in cases of multidrug-resistant (MDR-TB) tuberculosis. DESIGN: A retrospective review of the medical records of 263 patients who received individualised treatment for MDR-TB between April 1992 and June 2004. RESULTS: One or more side effects developed in 182 cases (69.2%). These effects led the clinicians to withdraw one or more drugs from the treatment regimen in 146 cases (55.5%). Side effects observed most frequently included: ototoxicity (41.8%), psychiatric disorders (21.3%), gastrointestinal disturbance (14.0%), arthralgia (11.4%), epileptic seizures (9.9%), hepatitis (4.5%), and dermatological effects (4.5%). At the time of analysis, treatment was successful in 204 (77.6%) cases. Fifty-nine patients (22.4%) had poor outcomes. CONCLUSION: Timely and aggressive management of drug side effects means that high side effect rates in MDR-TB treatment need not compromise success rates. © 2005 The Union.