The Role of Blood Count-Derived Inflammatory Indices in the Short-Term Prediction of Delivery in Women With Threatened Preterm Labor
American Journal of Reproductive Immunology, cilt.94, sa.1, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 94 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1111/aji.70126
- Dergi Adı: American Journal of Reproductive Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
- Anahtar Kelimeler: complete blood count, hemogram, immune, index, premature birth, preterm delivery, systemic inflammation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To investigate the association between inflammatory indices derived from complete blood count (CBC) and delivery within 1 week for threatened preterm labor (tPTL) in order to contribute to the management algorithm for women with tPTL. Materials and Methods: We conducted a retrospective cohort study of women with a singleton pregnancy and tPTL admitted to a large tertiary referral hospital between October 1, 2022, and May 31, 2023. After exclusion, the study groups were formed with 42 women who gave birth within 1 week of admission (group 1) and 84 women who gave birth later than 1 week after admission (group 2). The comparison focused mainly on whether there was a difference between the two groups in the systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune inflammation value (PIV), as well as other inflammatory indices. Results: Monocyte count, monocyte-to-lymphocyte ratio (MLR), SIRI, and PIV were significantly higher in group 1 (p = 0.038, 0.019, 0.029, and 0.037, respectively) and receiver operating characteristics curve analysis for discriminatory power to predict PTB within 1 week revealed area under the curve values of 0.613, 0.628, 0.620, and 0.614, respectively. The overall predictive power showed no significant superiority between the individual parameters. Conclusions: Our preliminary results showed an association between increased inflammatory indices and an increased risk of delivery within 1 week in women with tPTL. In particular, SIRI and PIV with cut-off values of >4.3 × 103/µL and >677 × 106/µL2 respectively may facilitate decision-making in the management algorithm for women with tPTL. Further randomized controlled trials with a larger cohort are needed to better define efficacy and limitations.