THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS
Istanbul Tip Fakultesi Dergisi, cilt.84, sa.2, ss.214-220, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 84 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.26650/iuitfd.2020.0060
- Dergi Adı: Istanbul Tip Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.214-220
- Anahtar Kelimeler: Arterial stiffness, mortality, chronic renal disease
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Pulse wave velocity (PWV) is frequently used for arterial stiffness assessment in chronic renal disease (CRD). There are very few studies in the literature about the relationship between arterial stiffness and renal progression leading to mortality in CRD. Herein, we searched the relationship between arterial stiffness, and progression of kidney disease, leading to mortality in CRD patients. Methods: 194 stage 3-5 CRD patients were included in the study. The patients were followed at least four years. The primary endpoints were initiation a renal replacement treatment and death. PWV was measured using the Mobil-O-Graph NG arteriography device. Results: The study was completed with 194 patients within four years. During this period, out of 194 patients, 89 needed a renal replacement treatment (72 hemodialysis patients, 17 renal transplantation) and 15 died. Ninety of them are still being followed as predialysis CKD patient in the nephrology outpatient clinic. Increased PWV was detected as an independent predictive marker of mortality. Conclusion: Our study demonstrated that PWV might be an independent predictor of mortality. In this sense, monitoring the PWV and taking measures in this direction can reduce the effect of arterial stiffness on mortality.