Biocompatible Dipeptide-Based Nanogels Incorporating Cinnamic Acid for Applications in Skin Disorder Therapy
Pharmaceutics, cilt.18, sa.2, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.3390/pharmaceutics18020173
- Dergi Adı: Pharmaceutics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Anahtar Kelimeler: Fmoc-FF, melanoma, wound healing, phytochemical
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background/Objectives: Skin-related disorders such as melanoma, premature aging, and chronic wounds significantly impact individuals’ quality of life and psychological well-being. Melanoma, due to its high metastatic potential and poor response to conventional chemotherapeutic agents, remains a major clinical challenge. Additionally, skin aging and impaired wound healing continue to drive the demand for novel therapeutic strategies and bioactive formulations. Methods: In this study, cinnamic acid (CA), a naturally occurring compound with known anti-inflammatory and antioxidant properties, was incorporated into biocompatible Fmoc-FF dipeptide-based nanogels to improve its stability and therapeutic efficacy. The antitumor effects of CA and CA-loaded nanogels were evaluated using human melanoma (SK-MEL-30) cells, while wound healing activity was assessed on human keratinocyte (HaCaT) cells. Results: The results demonstrated that CA exhibited significant activity against melanoma cells and promoted wound healing, with enhanced effects observed when delivered via Fmoc-FF nanogels. Conclusions: These findings suggest that CA-loaded peptide nanogels represent a promising platform for multifunctional treatment approaches targeting various skin disorders.