Investigation of the relationship between uterine artery Doppler diastolic notching and serum apelin-13 and apelin-36 concentrations between the 11th and 14th weeks of pregnancy: a case-control study
Pan African Medical Journal, cilt.52, 2025 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52
- Basım Tarihi: 2025
- Doi Numarası: 10.11604/pamj.2025.52.82.44289
- Dergi Adı: Pan African Medical Journal
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: Apelin-13, apelin-36, diastolic notching, pregnancy, uterine artery
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Introduction: the apelin family plays a role in the proliferation and migration of trophoblasts. Based on this, we aimed to investigate the relationship between diastolic notching in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations between 11 and 14 weeks of gestation. Methods: forty-four (44) pregnant women with diastolic notching in uterine artery Doppler and 44 without diastolic notching were compared in terms of serum apelin-13 and apelin-36 concentrations. Results: the two groups were similar in terms of demographic characteristics (p > 0.05). The median apelin-13 concentration was found to be 45.4 pg/mL in the uterine artery notch-positive group, while it was 41.02 pg/mL in the uterine artery notch-negative group (p = 0.770). The median apelin-36 concentration was 546.06 pg/mL in the uterine artery notch-positive group, while it was 536.6 pg/mL in the uterine artery notch-negative group (p = 0.570). Participants were regrouped as high or normal pulsatility index (PI) according to uterine artery PI, and both groups were compared in terms of apelin-13 and apelin-36 concentrations. Median serum apelin-13 and apelin-36 concentrations were also similar in the high and normal uterine artery PI groups (p = 0.445, p = 0.402, respectively). Conclusion: although the number of participants was too small to draw a definitive conclusion, no significant relationship between diastolic notching or increased resistance in the uterine artery and serum apelin-13 and apelin-36 concentrations could be detected.